If pay-for-play sex is what your after, and assuming you are located stateside, your best bet is to take a trip to Nevada and head out to one of the ten counties outside of Las Vegas where prostitution is legal and (somewhat) regulated. It will be pricey, but your experience is less likely to be a total disaster.
Otherwise, wait for the pandemic to subside and book a flight to Amsterdam, where prostitution is legal, well-regulated and considered to be just another way to make a living. The prostitutes even have a workers union. Amsterdam has an entire district in the city devoted to the sex trade and you can find whatever it is you are longing for, from the tame to as wild as you want to get. It's comparatively safe as the police are never far away. Most of the crime is small time petty stuff, like pickpockets, etc. Violence is uncommon, but is not unheard of.
Otherwise, you're playing with fire. Aside from those ten counties in Nevada, prostitution is illegal in every other county in every other state. Prostitution is almost entirely run by organized crime, either small scale pimps or syndicated crime organizations (i.e., mafia, drug gangs, biker gangs, etc.) Most call girls are drug users of some kind and hook to support their habits and/or the habits of their pimps. And many wouldn't have any qualms about slipping you a roofie and making off making off with whatever they can steal. Prostitution is a dirty, illegal business and there is nothing "safe" about it.